Who wins Zilean vs Karma Support in Patch 16.5?

In Patch 16.5 Emerald+ ranked games, Zilean has a 50.5% win rate and Karma has a 51.2% win rate in Support. Karma has the statistical edge with a 0.7% win rate advantage.

How do I play the Zilean vs Karma matchup?

Use Meridian Zero's matchup analysis tool for detailed trading patterns, power spike windows, and win conditions for Zilean vs Karma in Support. Both champions' optimal builds, runes, and skill orders are shown on this page.

Zilean vs Karma Support

Q: What is the best build for Zilean against Karma?

The optimal Zilean build starts with Spellthief's Edge and Health Potion. Core items are Blackfire Torch, Rylai's Crystal Scepter, Morellonomicon with Sorcerer's Shoes. Run Summon Aery from Sorcery with Resolve secondary.

Q: What is the best build for Karma against Zilean?

The optimal Karma build starts with Spellthief's Edge and Health Potion. Core items are Blackfire Torch, Rylai's Crystal Scepter, Morellonomicon with Sorcerer's Shoes. Run Summon Aery from Sorcery with Resolve secondary.

Patch 16.5 · Emerald+ Ranked · Meridian Zero Data

In the Zilean vs Karma Support matchup on Patch 16.5, Zilean has a 50.5% win rate (A tier) while Karma has a 51.2% win rate (S+ tier) in Emerald+ ranked games. Karma has the statistical edge with a 0.7% win rate advantage. Below are the optimal builds, runes, and skill orders for both champions in this matchup, sourced from OP.GG Emerald+ data.

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Zilean

A Tier 50.5% WR

StartSpellthief's EdgeHealth Potion

CoreBlackfire TorchRylai's Crystal ScepterMorellonomicon

BootsSorcerer's Shoes

SpellsFlashIgnite

SkillsQ > W > E

KeystoneSummon Aery

PrimarySorcery

SecondaryResolve

Karma

S+ Tier 51.2% WR