Who wins Vayne vs Caitlyn Bot Lane in Patch 16.5?

In Patch 16.5 Emerald+ ranked games, Vayne has a 50.6% win rate and Caitlyn has a 49.5% win rate in Bot Lane. Vayne has the statistical edge with a 1.1% win rate advantage.

What is the best build for Vayne against Caitlyn?

The optimal Vayne build starts with Doran's Blade and Health Potion. Core items are Infinity Edge, Phantom Dancer, Bloodthirster with Berserker's Greaves. Run Lethal Tempo from Precision with Domination secondary.

What is the best build for Caitlyn against Vayne?

The optimal Caitlyn build starts with Doran's Blade and Health Potion. Core items are Infinity Edge, Phantom Dancer, Bloodthirster with Berserker's Greaves. Run Lethal Tempo from Precision with Domination secondary.

How do I play the Vayne vs Caitlyn matchup?

Use Meridian Zero's matchup analysis tool for detailed trading patterns, power spike windows, and win conditions for Vayne vs Caitlyn in Bot Lane. Both champions' optimal builds, runes, and skill orders are shown on this page.

Vayne vs Caitlyn Bot Lane

Patch 16.5 · Emerald+ Ranked · Meridian Zero Data

In the Vayne vs Caitlyn Bot Lane matchup on Patch 16.5, Vayne has a 50.6% win rate (A tier) while Caitlyn has a 49.5% win rate (S tier) in Emerald+ ranked games. Vayne has the statistical edge with a 1.1% win rate advantage. Below are the optimal builds, runes, and skill orders for both champions in this matchup, sourced from OP.GG Emerald+ data.

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Vayne

A Tier 50.6% WR

StartDoran's BladeHealth Potion

CoreInfinity EdgePhantom DancerBloodthirster

BootsBerserker's Greaves

SpellsFlashHeal

SkillsQ > W > E

KeystoneLethal Tempo

PrimaryPrecision

SecondaryDomination

Caitlyn

S Tier 49.5% WR