Who wins Seraphine vs Karma Support in Patch 16.5?

In Patch 16.5 Emerald+ ranked games, Seraphine has a 51.2% win rate and Karma has a 51.2% win rate in Support. This is an even matchup based on overall win rates.

What is the best build for Seraphine against Karma?

The optimal Seraphine build starts with Spellthief's Edge and Health Potion. Core items are Blackfire Torch, Rylai's Crystal Scepter, Morellonomicon with Sorcerer's Shoes. Run Summon Aery from Sorcery with Resolve secondary.

How do I play the Seraphine vs Karma matchup?

Use Meridian Zero's matchup analysis tool for detailed trading patterns, power spike windows, and win conditions for Seraphine vs Karma in Support. Both champions' optimal builds, runes, and skill orders are shown on this page.

Seraphine vs Karma Support

Q: What is the best build for Karma against Seraphine?

The optimal Karma build starts with Spellthief's Edge and Health Potion. Core items are Blackfire Torch, Rylai's Crystal Scepter, Morellonomicon with Sorcerer's Shoes. Run Summon Aery from Sorcery with Resolve secondary.

Patch 16.5 · Emerald+ Ranked · Meridian Zero Data

In the Seraphine vs Karma Support matchup on Patch 16.5, Seraphine has a 51.2% win rate (S tier) while Karma has a 51.2% win rate (S+ tier) in Emerald+ ranked games. This is an even matchup based on overall win rates. Below are the optimal builds, runes, and skill orders for both champions in this matchup, sourced from OP.GG Emerald+ data.

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Seraphine

S Tier 51.2% WR

StartSpellthief's EdgeHealth Potion

CoreBlackfire TorchRylai's Crystal ScepterMorellonomicon

BootsSorcerer's Shoes

SpellsFlashIgnite

SkillsQ > W > E

KeystoneSummon Aery

PrimarySorcery

SecondaryResolve

Karma

S+ Tier 51.2% WR