Who wins Senna vs Nautilus Support in Patch 16.5?

In Patch 16.5 Emerald+ ranked games, Senna has a 51.4% win rate and Nautilus has a 48.8% win rate in Support. Senna has the statistical edge with a 2.6% win rate advantage.

How do I play the Senna vs Nautilus matchup?

Use Meridian Zero's matchup analysis tool for detailed trading patterns, power spike windows, and win conditions for Senna vs Nautilus in Support. Both champions' optimal builds, runes, and skill orders are shown on this page.

Senna vs Nautilus Support

Q: What is the best build for Senna against Nautilus?

The optimal Senna build starts with Spellthief's Edge and Health Potion. Core items are Moonstone Renewer, Staff of Flowing Water, Redemption with Boots of Lucidity. Run Guardian from Resolve with Inspiration secondary.

Q: What is the best build for Nautilus against Senna?

The optimal Nautilus build starts with Relic Shield and Health Potion. Core items are Locket of the Iron Solari, Knight's Vow, Zeke's Convergence with Plated Steelcaps. Run Guardian from Resolve with Inspiration secondary.

Patch 16.5 · Emerald+ Ranked · Meridian Zero Data

In the Senna vs Nautilus Support matchup on Patch 16.5, Senna has a 51.4% win rate (S tier) while Nautilus has a 48.8% win rate (S tier) in Emerald+ ranked games. Senna has the statistical edge with a 2.6% win rate advantage. Below are the optimal builds, runes, and skill orders for both champions in this matchup, sourced from OP.GG Emerald+ data.

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Senna

S Tier 51.4% WR

StartSpellthief's EdgeHealth Potion

CoreMoonstone RenewerStaff of Flowing WaterRedemption

BootsBoots of Lucidity

SpellsFlashIgnite

SkillsQ > W > E

KeystoneGuardian

PrimaryResolve

SecondaryInspiration

Nautilus

S Tier 48.8% WR

StartRelic ShieldHealth Potion

CoreLocket of the Iron SolariKnight's VowZeke's Convergence

BootsPlated Steelcaps

SpellsFlashIgnite

SkillsQ > W > E

KeystoneGuardian

PrimaryResolve

SecondaryInspiration

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Senna vs Nautilus Support

Senna

Nautilus

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