Senna vs Nautilus Support

Patch 16.5 · Emerald+ Ranked · Meridian Zero Data

In the Senna vs Nautilus Support matchup on Patch 16.5, Senna has a 51.4% win rate (S tier) while Nautilus has a 48.8% win rate (S tier) in Emerald+ ranked games. Senna has the statistical edge with a 2.6% win rate advantage. Below are the optimal builds, runes, and skill orders for both champions in this matchup, sourced from OP.GG Emerald+ data.

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Senna

Senna

S Tier 51.4% WR
StartSpellthief's EdgeHealth Potion
CoreMoonstone RenewerStaff of Flowing WaterRedemption
BootsBoots of Lucidity
SpellsFlashIgnite
SkillsQ > W > E
KeystoneGuardian
PrimaryResolve
SecondaryInspiration
Nautilus

Nautilus

S Tier 48.8% WR
StartRelic ShieldHealth Potion
CoreLocket of the Iron SolariKnight's VowZeke's Convergence
BootsPlated Steelcaps
SpellsFlashIgnite
SkillsQ > W > E
KeystoneGuardian
PrimaryResolve
SecondaryInspiration

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