Who wins Pantheon vs Karma Support in Patch 16.5?

In Patch 16.5 Emerald+ ranked games, Pantheon has a 49.0% win rate and Karma has a 51.2% win rate in Support. Karma has the statistical edge with a 2.1% win rate advantage.

What is the best build for Pantheon against Karma?

The optimal Pantheon build starts with Spellthief's Edge and Health Potion. Core items are Moonstone Renewer, Staff of Flowing Water, Redemption with Boots of Lucidity. Run Guardian from Resolve with Inspiration secondary.

How do I play the Pantheon vs Karma matchup?

Use Meridian Zero's matchup analysis tool for detailed trading patterns, power spike windows, and win conditions for Pantheon vs Karma in Support. Both champions' optimal builds, runes, and skill orders are shown on this page.

Pantheon vs Karma Support

Q: What is the best build for Karma against Pantheon?

The optimal Karma build starts with Spellthief's Edge and Health Potion. Core items are Blackfire Torch, Rylai's Crystal Scepter, Morellonomicon with Sorcerer's Shoes. Run Summon Aery from Sorcery with Resolve secondary.

Patch 16.5 · Emerald+ Ranked · Meridian Zero Data

In the Pantheon vs Karma Support matchup on Patch 16.5, Pantheon has a 49.0% win rate (A tier) while Karma has a 51.2% win rate (S+ tier) in Emerald+ ranked games. Karma has the statistical edge with a 2.1% win rate advantage. Below are the optimal builds, runes, and skill orders for both champions in this matchup, sourced from OP.GG Emerald+ data.

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Pantheon

A Tier 49.0% WR

StartSpellthief's EdgeHealth Potion

CoreMoonstone RenewerStaff of Flowing WaterRedemption

BootsBoots of Lucidity

SpellsFlashIgnite

SkillsQ > E > W

KeystoneGuardian

PrimaryResolve

SecondaryInspiration

Karma

S+ Tier 51.2% WR

StartSpellthief's EdgeHealth Potion

CoreBlackfire TorchRylai's Crystal ScepterMorellonomicon

BootsSorcerer's Shoes

SpellsFlashIgnite

SkillsQ > W > E

KeystoneSummon Aery

PrimarySorcery

SecondaryResolve

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Pantheon vs Karma Support

Pantheon

Karma

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