Who wins Karma vs Zyra Support in Patch 16.5?

In Patch 16.5 Emerald+ ranked games, Karma has a 51.2% win rate and Zyra has a 50.9% win rate in Support. Karma has the statistical edge with a 0.3% win rate advantage.

How do I play the Karma vs Zyra matchup?

Use Meridian Zero's matchup analysis tool for detailed trading patterns, power spike windows, and win conditions for Karma vs Zyra in Support. Both champions' optimal builds, runes, and skill orders are shown on this page.

Karma vs Zyra Support

Q: What is the best build for Karma against Zyra?

The optimal Karma build starts with Spellthief's Edge and Health Potion. Core items are Blackfire Torch, Rylai's Crystal Scepter, Morellonomicon with Sorcerer's Shoes. Run Summon Aery from Sorcery with Resolve secondary.

Q: What is the best build for Zyra against Karma?

The optimal Zyra build starts with Spellthief's Edge and Health Potion. Core items are Blackfire Torch, Rylai's Crystal Scepter, Morellonomicon with Sorcerer's Shoes. Run Summon Aery from Sorcery with Resolve secondary.

Patch 16.5 · Emerald+ Ranked · Meridian Zero Data

In the Karma vs Zyra Support matchup on Patch 16.5, Karma has a 51.2% win rate (S+ tier) while Zyra has a 50.9% win rate (A tier) in Emerald+ ranked games. Karma has the statistical edge with a 0.3% win rate advantage. Below are the optimal builds, runes, and skill orders for both champions in this matchup, sourced from OP.GG Emerald+ data.

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Karma

S+ Tier 51.2% WR

StartSpellthief's EdgeHealth Potion

CoreBlackfire TorchRylai's Crystal ScepterMorellonomicon

BootsSorcerer's Shoes

SpellsFlashIgnite

SkillsQ > W > E

KeystoneSummon Aery

PrimarySorcery

SecondaryResolve

Zyra

A Tier 50.9% WR