Ezreal vs Senna Bot Lane

Patch 16.5 · Emerald+ Ranked · Meridian Zero Data

In the Ezreal vs Senna Bot Lane matchup on Patch 16.5, Ezreal has a 48.5% win rate (A tier) while Senna has a 50.3% win rate (B tier) in Emerald+ ranked games. Senna has the statistical edge with a 1.8% win rate advantage. Below are the optimal builds, runes, and skill orders for both champions in this matchup, sourced from OP.GG Emerald+ data.

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Ezreal

Ezreal

A Tier 48.5% WR
StartDoran's BladeHealth Potion
CoreInfinity EdgePhantom DancerBloodthirster
BootsBerserker's Greaves
SpellsFlashHeal
SkillsQ > W > E
KeystoneLethal Tempo
PrimaryPrecision
SecondaryDomination
Senna

Senna

B Tier 50.3% WR
StartSpellthief's EdgeHealth Potion
CoreMoonstone RenewerStaff of Flowing WaterRedemption
BootsBoots of Lucidity
SpellsFlashHeal
SkillsQ > W > E
KeystoneLethal Tempo
PrimaryPrecision
SecondaryDomination

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