Who wins Ezreal vs Senna Bot Lane in Patch 16.5?

In Patch 16.5 Emerald+ ranked games, Ezreal has a 48.5% win rate and Senna has a 50.3% win rate in Bot Lane. Senna has the statistical edge with a 1.8% win rate advantage.

What is the best build for Ezreal against Senna?

The optimal Ezreal build starts with Doran's Blade and Health Potion. Core items are Infinity Edge, Phantom Dancer, Bloodthirster with Berserker's Greaves. Run Lethal Tempo from Precision with Domination secondary.

How do I play the Ezreal vs Senna matchup?

Use Meridian Zero's matchup analysis tool for detailed trading patterns, power spike windows, and win conditions for Ezreal vs Senna in Bot Lane. Both champions' optimal builds, runes, and skill orders are shown on this page.

Ezreal vs Senna Bot Lane

Q: What is the best build for Senna against Ezreal?

The optimal Senna build starts with Spellthief's Edge and Health Potion. Core items are Moonstone Renewer, Staff of Flowing Water, Redemption with Boots of Lucidity. Run Lethal Tempo from Precision with Domination secondary.

Patch 16.5 · Emerald+ Ranked · Meridian Zero Data

In the Ezreal vs Senna Bot Lane matchup on Patch 16.5, Ezreal has a 48.5% win rate (A tier) while Senna has a 50.3% win rate (B tier) in Emerald+ ranked games. Senna has the statistical edge with a 1.8% win rate advantage. Below are the optimal builds, runes, and skill orders for both champions in this matchup, sourced from OP.GG Emerald+ data.

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Ezreal

A Tier 48.5% WR

StartDoran's BladeHealth Potion

CoreInfinity EdgePhantom DancerBloodthirster

BootsBerserker's Greaves

SpellsFlashHeal

SkillsQ > W > E

KeystoneLethal Tempo

PrimaryPrecision

SecondaryDomination

Senna

B Tier 50.3% WR

StartSpellthief's EdgeHealth Potion

CoreMoonstone RenewerStaff of Flowing WaterRedemption

BootsBoots of Lucidity

SpellsFlashHeal

SkillsQ > W > E

KeystoneLethal Tempo

PrimaryPrecision

SecondaryDomination

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Ezreal vs Senna Bot Lane

Ezreal

Senna

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