Who wins Caitlyn vs Miss Fortune Bot Lane in Patch 16.5?

In Patch 16.5 Emerald+ ranked games, Caitlyn has a 49.5% win rate and Miss Fortune has a 51.2% win rate in Bot Lane. Miss Fortune has the statistical edge with a 1.6% win rate advantage.

What is the best build for Caitlyn against Miss Fortune?

The optimal Caitlyn build starts with Doran's Blade and Health Potion. Core items are Infinity Edge, Phantom Dancer, Bloodthirster with Berserker's Greaves. Run Lethal Tempo from Precision with Domination secondary.

What is the best build for Miss Fortune against Caitlyn?

The optimal Miss Fortune build starts with Doran's Blade and Health Potion. Core items are Infinity Edge, Phantom Dancer, Bloodthirster with Berserker's Greaves. Run Lethal Tempo from Precision with Domination secondary.

How do I play the Caitlyn vs Miss Fortune matchup?

Use Meridian Zero's matchup analysis tool for detailed trading patterns, power spike windows, and win conditions for Caitlyn vs Miss Fortune in Bot Lane. Both champions' optimal builds, runes, and skill orders are shown on this page.

Caitlyn vs Miss Fortune Bot Lane

Patch 16.5 · Emerald+ Ranked · Meridian Zero Data

In the Caitlyn vs Miss Fortune Bot Lane matchup on Patch 16.5, Caitlyn has a 49.5% win rate (S tier) while Miss Fortune has a 51.2% win rate (S tier) in Emerald+ ranked games. Miss Fortune has the statistical edge with a 1.6% win rate advantage. Below are the optimal builds, runes, and skill orders for both champions in this matchup, sourced from OP.GG Emerald+ data.

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Caitlyn

S Tier 49.5% WR

StartDoran's BladeHealth Potion

CoreInfinity EdgePhantom DancerBloodthirster

BootsBerserker's Greaves

SpellsFlashHeal

SkillsQ > W > E

KeystoneLethal Tempo

PrimaryPrecision

SecondaryDomination

Miss Fortune

S Tier 51.2% WR