What is the best build for Lissandra Mid Lane in Patch 16.5?

The optimal Lissandra Mid Lane build starts with Doran's Ring and Health Potion. Core items are Luden's Companion, Shadowflame, Rabadon's Deathcap with Sorcerer's Shoes. Run Flash and Teleport as summoner spells.

What runes should I use on Lissandra Mid Lane?

Lissandra Mid Lane runs Arcane Comet as the keystone in Sorcery with Manaflow Band, Transcendence, and Scorch. Secondary tree is Inspiration with Biscuit Delivery and Cosmic Insight.

Is Lissandra good in Patch 16.5?

Lissandra is B tier in Mid Lane with a 48.5% win rate in Emerald+ ranked games on Patch 16.5, according to OP.GG data. Lissandra requires more skill investment to succeed with.

What are Lissandra's power spikes in Mid Lane?

Lissandra hits a significant power spike when completing Luden's Companion. The two-item spike with Luden's Companion and Shadowflame is when Lissandra becomes a major threat. Skill priority is Q > W > E, so maxing the primary ability first accelerates early-game power.

When should I pick Lissandra in ranked?

Lissandra is a B tier Mid Lane pick in Patch 16.5 with a 3.0% pick rate. Lissandra works well as a Mage and fits team compositions that need magic damage and zone control.

What summoner spells should I run on Lissandra Mid Lane?

The recommended summoner spells for Lissandra Mid Lane are Flash and Teleport. This is the highest win-rate combination in Emerald+ ranked games on Patch 16.5.

What is Lissandra's hardest matchup in Mid Lane?

Diana is one of the toughest Mid Lane matchups for Lissandra. Diana is S+ tier with a 53.4% win rate. Use Meridian Zero's matchup analysis tool to get detailed trading patterns and win conditions for Lissandra vs Diana.

Lissandra Mid Lane Guide — Patch 16.5 Builds, Runes & Matchups

Lissandra is a B tier Mid Lane champion in League of Legends Patch 16.5 with a 48.5% win rate in Emerald+ ranked games, according to OP.GG data. The optimal Lissandra build starts with Doran's Ring and Health Potion, with core items being Luden's Companion, Shadowflame, Rabadon's Deathcap and Sorcerer's Shoes. For runes, run Arcane Comet from Sorcery with Inspiration as the secondary tree. Skill priority is Q > W > E. Lissandra is best played with Flash and Teleport as summoner spells. The most challenging matchup in Mid Lane is Diana (S+ tier, 53.4% win rate).

Source: OP.GG Emerald+ ranked data, Patch 16.5 · Last updated: March 2026 · Meridian Zero Analytics

Best Build — Patch 16.5

Start Doran's RingHealth Potion

Core Luden's CompanionShadowflameRabadon's Deathcap

Boots Sorcerer's Shoes

Spells FlashTeleport

Priority Q > W > E

Expert Tips

Your passive (Iceborn) grants temporary free abilities. Use it on Q for a free push or W for a free engage.
Glacial Path (E) reposition at 180 degrees from the initial cast by activating again — use it to dodge ganks.
Frozen Tomb (R) on yourself is a powerful survival tool. Use it on yourself when being focused in teamfights.

Mid Lane Matchups — Difficulty by Opponent

Opponent	Tier	Difficulty
Diana	S+	Hard	Analyze →
Ahri	S+	Hard	Analyze →
Zed	S+	Hard	Analyze →
Vex	S	Hard	Analyze →
Fizz	S	Hard	Analyze →
Zoe	S	Hard	Analyze →
Aurelion Sol	S	Hard	Analyze →
Twisted Fate	S	Hard	Analyze →
Xerath	S	Hard	Analyze →
Katarina	S	Hard	Analyze →
Mel	S	Hard	Analyze →
Sylas	S	Hard	Analyze →

Runes — Patch 16.5

KeystoneArcane Comet

Primary TreeSorcery

Slot 1Manaflow Band

Slot 2Transcendence

Slot 3Scorch

Secondary TreeInspiration

Secondary 1Biscuit Delivery

Secondary 2Cosmic Insight